Retinol has long been the gold-standard in anti-aging skincare, but it often comes with unwelcome side effects like irritation and sun sensitivity. Enter bakuchiol, a natural compound garnering attention as a gentler yet effective “retinol alternative.”
Key takeaways:
- Bakuchiol delivers retinol-like anti-aging results with significantly less irritation
- It’s suitable for sensitive skin, daytime use, and often chosen during pregnancy
- Clinical studies show comparable efficacy to retinol in reducing wrinkles and improving skin texture
- EOCEL’s Odaan Anti-Aging Face Cream uses clinically backed 1% bakuchiol in a 100% natural, COSMOS-compliant base
Early comparisons show that while retinol and bakuchiol share many benefits—from boosting collagen and smoothing wrinkles to fading pigmentation—bakuchiol stands out for its superior tolerability.
Unlike retinol, bakuchiol doesn’t typically cause peeling, burning, or photosensitivity, making it suitable for sensitive skin and even daytime use.
This article will explore bakuchiol in depth: what it is, how it works, the science behind its anti-aging effects, and why products like EOCEL’s Odaan Anti-Aging Face Cream leverage bakuchiol to deliver retinol-like results without the downsides.
What is Bakuchiol?
Bakuchiol is a naturally occurring compound extracted from the seeds and leaves of the Psoralea corylifolia plant, also known as babchi. This plant has a long history in traditional Ayurvedic and Chinese medicine, where it was primarily used to treat various skin conditions, including vitiligo, psoriasis, and inflammation.
Chemically speaking, bakuchiol is a meroterpene—a class of molecules that are part terpenoid (derived from plant oils) and part phenol (an aromatic compound). Its structure is completely different from retinol (vitamin A).
Despite this different structure, pioneering studies revealed that bakuchiol can act as a functional analog of retinol in the skin. In other words, it triggers many of the same pathways and skin benefits as retinol—such as collagen production and cell turnover—but through its own unique mechanism.
This has earned bakuchiol nicknames like “plant-based retinol,” reflecting its ability to promote smoother, firmer, more even-toned skin without the typical irritation associated with retinoid products.
Key Properties
Bakuchiol’s rising popularity is due to a convergence of desirable properties that make it an attractive alternative (or complement) to retinol:
- Natural & plant‑derived – Extracted from the babchi plant, offering a botanical, vegan-friendly option
- Retinol‑like anti-aging – Reduces wrinkles, improves elasticity, and stimulates collagen production
- Gentle on skin – Excellent tolerability, even at 1% concentration, with minimal irritation
- Photosafe – Stable in sunlight and suitable for both morning and night application
- Pregnancy‑friendly – Not a vitamin A derivative and generally considered safe during pregnancy
- Antioxidant & antimicrobial – Neutralizes free radicals and helps keep pores clear
- Stable & compatible – Plays well with acids, niacinamide, peptides, and other actives
The Science: How It Works
Bakuchiol’s gentle nature doesn’t mean it’s “weak”—on the contrary, it affects the skin in multiple scientific ways reminiscent of retinoids.
Here’s a closer look at the mechanisms by which bakuchiol rejuvenates skin:
Gene Expression Modulation
One of the most fascinating discoveries about bakuchiol is that it can modulate gene expression in skin cells similarly to retinol. In a landmark study, researchers compared the gene expression profiles induced by bakuchiol and retinol in a full-thickness skin model.
The result: striking overall similarity between the two.
In other words, bakuchiol turned on and off many of the same genes that retinol does—even though, chemically, it’s a completely different molecule.
Bakuchiol upregulates genes responsible for collagen synthesis (types I, III, and IV) and dermal matrix formation.
Increased collagen production helps strengthen the skin’s support structure, reducing wrinkle depth and improving firmness. At the same time, bakuchiol downregulates collagen-degrading enzymes and other factors involved in skin aging, effectively slowing the breakdown of the skin matrix.
Cell Turnover and Renewal
Much like retinol, bakuchiol encourages the shedding of old, damaged cells and promotes the generation of new ones. This process, often referred to as epidermal turnover, is essential for maintaining smooth, youthful-looking skin.
When the outer layer of skin is renewed more efficiently, it means fewer dead cells accumulate on the surface. Consequently, the complexion appears brighter, smoother, and more radiant.
Antioxidant Activity
Bakuchiol possesses significant antioxidant properties, meaning it can neutralize harmful free radicals that contribute to aging and cellular damage. Free radicals—unstable molecules formed by UV exposure, pollution, and stress—attack skin cells and degrade collagen and elastin over time.
One lab study found bakuchiol outperformed retinol in antioxidative capacity, helping buffer skin against UV-induced free radicals.
Additionally, bakuchiol’s antioxidant nature contributes to its stability (it’s less prone to oxidative breakdown than retinol is) and may impart some photoprotection. Of course, bakuchiol is not a substitute for sunscreen, but by neutralizing free radicals generated by UV exposure, it can complement sun protection and reduce UV-triggered collagen degradation.
Anti-Inflammatory Effects
Inflammation is a key driver of skin aging and many skin concerns, from acne to sensitivity to rosacea. While retinol can sometimes initially aggravate inflammation (causing redness, peeling, or burning), bakuchiol is known for its anti-inflammatory properties.
Unlike retinol, bakuchiol actively calms inflammatory signals, which is why it’s so well-tolerated on sensitive and redness-prone skin.
Clinically, this translates to less redness and irritation. Not only does bakuchiol avoid causing inflammation, it actively counteracts it—which is why people with sensitive or redness-prone skin often find their complexion actually looks calmer and more even with regular bakuchiol use.
Its anti-inflammatory and antibacterial effects also tie into improvements in acne: studies note bakuchiol can reduce acne lesions by fighting bacteria and soothing acne-related irritation. Moreover, bakuchiol has been observed to accelerate wound healing in skin models, helping the skin repair itself from damage more efficiently.
Clinical Evidence
While understanding the science at a cellular level is fascinating, the ultimate question is: Does bakuchiol actually work in real-world use?
The answer, according to peer-reviewed clinical trials, is a resounding yes.
Head-to-Head Comparison with Retinol
One of the most cited studies on bakuchiol was a 12-week, double-blind, randomized trial published in the British Journal of Dermatology (2019). Researchers recruited 44 participants with facial photodamage (sun-induced aging) and assigned them to use either:
- 0.5% retinol cream (applied nightly), or
- 0.5% bakuchiol cream (applied twice daily: morning and night)
After 12 weeks, both groups showed significant improvement in:
- Wrinkle surface area and depth
- Hyperpigmentation (dark spots)
- Overall skin texture and firmness
- Elasticity and radiance
The critical finding: There was no statistically significant difference in efficacy between the bakuchiol and retinol groups. In other words, bakuchiol users achieved the same anti-aging improvements as the retinol group.
But here’s where it gets interesting: The bakuchiol group experienced far less scaling and stinging. The retinol group, as expected, reported more dryness, peeling, and irritation—common retinol side effects. Bakuchiol users, on the other hand, had minimal irritation.
“Clinically significant similarity to topical retinol in efficacy and superiority in tolerability and safety.” — Dermatology Review, 2019
Longer-Term Studies
Longer-Term Use (24 Weeks) – A 24-week follow-up study of a bakuchiol-containing regimen showed continued improvement over time—with significant enhancements in skin texture, tone, and reduction of redness by 24 weeks, and no serious side effects apart from a few reports of mild tingling or dryness early on.
Across these studies, a consistent theme emerges: bakuchiol delivers notable anti-aging improvements with minimal irritation. Participants end up with smoother, firmer, more even skin—often indistinguishable from retinol-treated skin in terms of results—but far more comfortable during the process.
Who Should Use Bakuchiol?
One of bakuchiol’s greatest strengths is its broad suitability. The groups who tend to benefit most are:
- Sensitive skin – Reactive, redness-prone, or eczema/rosacea-prone skin that cannot tolerate retinol’s harshness
- Retinol‑intolerant – Those who’ve experienced peeling, burning, or hyperpigmentation with retinoids
- Pregnant or nursing – People avoiding vitamin A derivatives but wanting to maintain an anti-aging routine
- New to anti‑aging – First-time active users who want gentle collagen support without a “purge” period
- Daytime skincare users – Those wanting a photostable active in their morning routine without sun sensitivity
- Acne‑prone – Adult acne with sensitivity, where anti-inflammatory and antibacterial action matters
While bakuchiol is generally well-tolerated, there are a few scenarios where caution or avoidance might be warranted:
-
Allergy to the Psoralea plant – If you have a known allergy to babchi or related plants, avoid bakuchiol
-
Patch test if unsure – While rare, some individuals may react to bakuchiol. If you have highly reactive skin, always patch test
-
Not a retinol replacement for prescription needs – If you’re using prescription tretinoin for severe acne or dermatological conditions, consult your doctor before switching
-
Always use sunscreen – This isn’t an “avoid” so much as a reminder—just because bakuchiol itself is not sun-sensitizing doesn’t mean you can skip SPF
Implementation Guide: Starting Your Bakuchiol Journey
Ready to embrace the retinol alternative? Here’s a simple, step‑by‑step way to introduce bakuchiol into your skincare routine:
- Choose a quality product – Look for formulations with around 1% bakuchiol (the clinically studied concentration). EOCEL’s Odaan Anti-Aging Face Cream contains 1% pure bakuchiol in a COSMOS-certified natural base
- Patch test if you’re sensitive – Apply a small amount to your inner arm or behind your ear for 24 hours before using on your face
- Start once daily at night – Begin with evening application after cleansing and toning. Once your skin adjusts (typically 1-2 weeks), you can add morning application if desired
- Layer correctly – Apply bakuchiol after water-based serums but before heavier creams. If using a bakuchiol cream like Odaan, it can serve as your moisturizer
- Watch and adjust – Monitor your skin’s response. If you notice any dryness (rare but possible), reduce frequency or pair with a bland, barrier-supporting moisturizer
- Protect with SPF – Use broad-spectrum SPF 30+ every morning to preserve your anti-aging results and protect against photoaging
- Stay consistent – Like retinol, bakuchiol works best with regular use. Expect to see the most visible improvements around 8–12 weeks
- Build a supportive routine – Combine with gentle cleansing, adequate hydration, and other complementary actives like antioxidants for maximum benefit
The Future of Bakuchiol
As research continues and consumer awareness grows, bakuchiol is poised to become a mainstream staple in anti-aging skincare.
Ongoing research directions:
-
Combination studies – Researchers are exploring how bakuchiol works when combined with other actives like niacinamide, peptides, and vitamin C for synergistic effects
-
Mechanism clarification – While we know bakuchiol acts like retinol, scientists are still uncovering the precise molecular pathways it uses
-
New formulations – Expect to see bakuchiol in serums, oils, cleansers, and even makeup as formulators discover optimal delivery methods
-
Consumer awareness and availability – On the consumer side, bakuchiol has gone from obscure to trendy, and it’s on track to become a staple. Market analysis shows demand for bakuchiol products is growing steadily each year
EOCEL’s Commitment: Why We Chose Bakuchiol for Odaan
At EOCEL, our philosophy is to unite nature and science to create skincare that is both gentle and extraordinarily effective. That’s why we made bakuchiol the cornerstone of our flagship Odaan Anti-Aging Face Cream. Odaan symbolizes the elevation of the skin — the rise back to youth.
We wanted an ingredient that could deliver transformative anti-aging results for all skin types—including sensitive, reactive, and pregnancy-affected skin—without compromise.
Formulation highlights
- 1% pure bakuchiol at clinically backed levels for wrinkle smoothing and firming
- 100% natural, COSMOS/Ecocert‑certified base with no parabens, synthetic fragrance, or harsh alcohols
- Elegant oil‑in‑water emulsion that feels rich yet absorbs cleanly without greasiness
- Complementary actives including hyaluronic acid, vitamin E, and plant ceramides for barrier support
- Suitable for sensitive skin and generally considered safe during pregnancy
Users of Odaan Anti-Aging Face Cream can expect to see retinol-like results over consistent use: smoother fine lines, reduced wrinkle depth, firmer skin with improved elasticity, and a more even, radiant tone.
But they will notice what they don’t see: no red, flaky “retinol face,” no stinging upon application, no need to take breaks due to irritation.
Instead, the experience is nurturing. Many report their skin feels more hydrated and calm even as it undergoes visible renewal—a testament to the formula’s balance of actives like bakuchiol with nourishing support ingredients.
A return to origin. A return to youth.
Conclusion
Bakuchiol represents a remarkable convergence of traditional botanical wisdom and modern dermatological science. It offers a compelling solution for anyone seeking the anti-aging benefits of retinol without the irritation, sun sensitivity, or pregnancy concerns.
The science is clear: Bakuchiol can stimulate collagen, accelerate cell turnover, reduce wrinkles, fade hyperpigmentation, and improve overall skin texture—all while being gentle enough for sensitive skin and safe for daytime use.
The clinical evidence is robust: Studies confirm that bakuchiol performs comparably to retinol in efficacy while significantly outperforming it in tolerability.
The future is bright: As research expands and formulations improve, bakuchiol is set to become a cornerstone ingredient in modern skincare.
In the end, bakuchiol empowers people to care for their skin with less compromise—achieving the timeless goal of a smoother, firmer, radiant complexion, while preserving comfort and skin health.
That is the essence of modern skincare innovation: bakuchiol is leading the way to a future where aging gracefully doesn’t have to come at the cost of irritation.
It’s a true botanical triumph in the labs and on our skin—and at EOCEL, we’re excited to be part of this gentle revolution in anti-aging care.
-
Chaudhuri RK, Bojanowski K. “Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects.” Int J Cosmet Sci. 2014;36(3):221-230.
-
Dhaliwal S, Rybak I, Ellis SR, et al. “Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing.” Br J Dermatol. 2019;180(2):289-296.
-
Draelos ZD. “The latest cosmeceutical approaches for antiaging.” J Cosmet Dermatol. 2007;6(1):2-6.
-
Bhatia AC, Dover JS. “A comparison of the antioxidant capacity of retinol and bakuchiol.” J Drugs Dermatol. 2018;17(12):1305-1308.
-
Mukherjee S, Date A, Patravale V, et al. “Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety.” Clin Interv Aging. 2006;1(4):327-348.
-
Giribabu N, Kumar KE, Rekha SS, et al. “Chloroform extract of Psoralea corylifolia seeds ameliorates male reproductive toxicity.” Syst Biol Reprod Med. 2014;60(5):291-298.
-
Park K. “Role of micronutrients in skin health and function.” Biomol Ther (Seoul). 2015;23(3):207-217.
-
Fiume MM, Bergfeld WF, Belsito DV, et al. “Safety Assessment of Bakuchiol.” Int J Toxicol. 2021;40(2_suppl):22S-52S.